• Examination of the effects of HIV protease inhibitors (HIV-PIs) on the function of the novel s-DAPK-1 in Human Papilloma Virus (HPV)-related cervical cancers 

  Makgoo, Lillian (2025)

  Cervical cancer treatment continues to be every country’s nightmare due to ineffectiveness and non-specificity of the current therapeutic options, late diagnosis and chemo drug resistance. An escalating resistance of ...
• Exploration of the regulation of immunomodulatory genes by commelina benghalensis aqueous extra in breast cancer cells 

  Mnisi, Hellen Laura (2025)

  Cancer is a noteworthy global health issue, and according to predictions by the World Health Organization, the number of new cases was projected to increase to approximately 29-37 million by 2040, worldwide (WHO, 2020, ...
• Screening of carpobrotus edulis extracts for anticancer activity against cervical cancer cells 

  Phoogole, Walter (2024)

  Introduction: Cancer is a primary cause of death and a significant impediment towards extending the life expectancy of human-kind. In terms of both incidence and fatality rates, cervical cancer is the fourth most common ...
• The effects of curcumin derivatives on SARS-CoV-2 spike S1 protein induced oxidative stress on macrophage cells 

  Nkwana, Maureen Ramadimetsa (2025)

  The corona virus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged as a global health crisis that claimed almost 7 million lives and a total of more than ...
• The effects of flaveria trinervia and dicerocaryum seneciodes extracts on metastatic MDA-MB-231 breast cancer cells 

  Sebei, Tubake Theona (2025)

  Medicinal plants have been used for centuries in various traditional healing practices worldwide. Research has revealed some of these plants contain bioactive compounds with potential anticancer and antimetastatic properties. ...
• The effect of didox on the induction of cell death in lung cancer cells challenged with SARS-CoV 2 recombinant spike proteins 

  Hlope, Kamogelo Sesi (2024)

  Lung cancer still accounts for most deaths caused by cancer in South Africa. Patients with lung cancer are more susceptible to coronavirus disease 2019 (COVID-19) fatal consequences due to their reduced lung function and ...
• Examination of the potential anticancer activities and moleculer mechanics of drimia calcarata buld exctracts against different cancer cells 

  Laka, Kagiso (2023)

  Cancer remains uncurable, and the current treatment strategies are associated with inefficiency and adverse side effects. The majority of the populace relies on traditional doctors who prescribe medicinal plants to treat ...
• Induction of apoptosis in cervical and breast cancer cells using quinoxaline derivatives 

  Satekge, Tebogo Yvette (2024)

  Background: Cervical and breast cancers remain a public health concern in South Africa with an increasing rate of incidences and mortalities globally. Current treatment options are not only costly but also present undesirable ...
• The effect of long-term high-fat diet feeding on intestinal health of aged vervet monkeys 

  Mukhari, Ronaldo (2024)

  The consumption of Westernised high-fat diets (HFDs) dysregulates intestinal barrier components which may lead to subclinical systemic and tissue inflammation implicated in type 2 diabetes (T2D) development. It is essential ...
• Investigation of the anti-inflammatory and anti-invasiveness effects of momordica balsamina leaf methanol extract using triple-negative breast cancer cell line MDA-MB-321 

  Mohale, Tshwarelo Evidence (2023)

  Cancer is the world's second leading cause of death, with current treatments accompanied by a myriad of undesirable side effects. Medicinal plants contain chemoprotective and more tolerable phytochemicals for cancer ...
• Evaluation of molecular mechanism(s) associated with the anti-proliferative and apoptosis-including properties of the crude methanolic and semi-purified extracts of dicerocaryum species in jurkat t cells 

  Mphahlele, Raetahle Paulina (2008)

  Cancer is one of the largest single causes of death in both men and women worldwide. In the last decade, basic cancer research has produced remarkable advances in the understanding of cancer biology and genetics. Its control ...
• Apoptotic effects of lithium chloride on renal cells and potential alteration of renal antigens involved in systemic lupus erythematosus. 

  Lucas, Kirsten Clare (2008)

  Lithium, a prophylactic drug for the treatment of bipolar disorder, is used with caution due to many toxicity implications. In particular, lithium dosage and renal toxicity has to be constantly monitored in these ...
• Glut4 translocation augmentation effects of medicinal plants traditionally used for the management of type II diabetes mellitus 

  Beseni, Brian Kudakwashe (2017)

  Diabetes mellitus is a chronic metabolic disorder characterised by perpetual hyperglycaemia. Various oral pharmacological theraputic management strategies currently exist but are too expensive and having a host of ...
• Phytochemical analysis of Momordica cardiospermoides crude acetone and methanol leaf extracts and their effects on MDA-MB-231 cell migration and invasiveness 

  Kgakishe, Mante Dolly (2021)

  Drug discovery from medicinal plants continues to play an important role in the development of anticancer agents, this is because medicinal plants are reservoirs of bioactive compounds that exert a plethora of pharmacological ...
• Bidens pilosa extract and sub-fractions induce adipogenesis and exert glucose uptake in 3T3-L1 adipocytes 

  Tolo, M. M. (2020)

  Diabetes mellitus has become a global epidemic, particularly type 2 diabetes. Obesity is one of the causes of type 2 diabetes mellitus due to its link with induced insulin resistance. There is no cure for diabetes ...
• Determination of the molecular mechanism(s) involved in the pro-apoptotic activity of momordica balsamina acetone extract in lung A549 cancer cells 

  Mudalahothe, Maedza (2019)

  Plant-derived products have been used for years in the treatment of various ailments with low or no side effects. Thus, screening of medicinal plants for potential anticancer activity, in vitro, could help identify ...
• Evaluation of anticancer activity of momordica balsamina extracts and potential interactions with a conventional anticancer drug in colon cancer 

  Malemela, Kholofelo Mmanoko (2021)

  Cancer remains one of the leading causes of morbidity and mortality worldwide with an estimated 9.9 million deaths in 2020. Cancer treatment regimens such as chemotherapy and radiotherapy have over the years fallen short ...
• Cytoprotective effects of lithium on endothelial integrity and immune profiles induced by rift valley fever virus on huvec and raw 264.7 cells 

  Makola, Raymond Tshepiso (2021)

  Introduction: Rift Valley fever virus (RVFV) is an arthropod-born RNA zoonotic virus causing Rift Valley fever (RVF) disease. RVFV is prevalent across sub-Saharan Africa and the Arabian Peninsula with no existing effective ...
• Differential expressions of apoptotic genes in lung (A549) cancer cells established by treatment with senna italica extracts 

  Moloantoa, Malose Ivan (2021)

  Lung cancer is the most diagnosed cancer with an estimated 3 million deaths expected by 2035. Bioactive phytochemicals present in plants are preferred as anticancer therapeutic agents, due to their ability to differentiate ...
• Integrative analysis of the epigenetic modification in a breast cancer cell line treated with a bioactive extract of bidens pilosa 

  Chokoe, Pirwana Kholofelo (2021)

  Breast cancer is the leading cause of female deaths in the world. Varying types of therapy options are available, yet these conventional treatments for the malignancy are known to have numerous side effects. Similar to ...

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